Table 3.
Kidney disease-related characteristics of patients at the index date
| Variables | All patients N = 769 |
RP N = 426 |
SP N = 342 |
P value |
|---|---|---|---|---|
| Serum creatinine (mg/dl) | 1.12 ± 0.40 | 1.18 ± 0.40 | 1.04 ± 0.38 | <0.01 |
| eGFR (ml/min per 1.73 m2) | 68.3 ± 28.4 | 64.6 ± 27.5 | 72.9 ± 29.0 | <0.01 |
| Blood urea nitrogen (mg/dl) | 18.9±14.3 | 19.7±17.4 | 17.6±7.6 | 0.08 |
| Uric acid (mg/dl) | 5.7±1.6 | 5.9±1.5 | 5.4±1.6 | <0.01 |
| Urine PCR (mg/mg) | 160.6 ± 310.9 | 188.9 ± 341.6 | 114.3± 305.4 | 0.01 |
| CKD stage (%) | <0.01 | |||
| 1 | 229 (29.8) | 107 (25.1) | 122 (35.7) | |
| 2 | 259 (33.7) | 141 (33.1) | 118 (34.5) | |
| 3a | 134 (17.5) | 77 (18.1) | 57 (16.7) | |
| 3b | 146 (19.0) | 101 (23.7) | 45 (13.2) | |
| Mayo imaging classification | N = 394 | N = 285 | N = 109 | <0.01 |
| Class 1A | 26(6.6) | 3(1.1) | 23(21.1) | |
| Class 1B | 101(25.6) | 15(5.3) | 86(78.9) | |
| Class 1C | 149(37.8) | 149(52.3) | 0(0.0) | |
| Class 1D | 8(20.8) | 82(28.8) | 0(0.0) | |
| Class 1E | 36(9.1) | 36(12.6) | 0(0.0) | |
| HtTKV(ml/m) | 1002.8 ± 664.8 | 1211.6 ± 667.4 | 473.3 ± 207.6 | <0.01 |
| Kidney length by ultrasound (cm) | 13.5 ± 3.1 (N = 50) | 15.3 ± 3.0 (N = 17) | 12.6 ± 2.7 (N = 33) | <0.01 |
| Genetic test results | N = 256 | N = 181 | N = 75 | |
| PKD1 PT mutation | 118(46.1) | 95(52.5) | 23(30.7) | <0.01 |
| PKD1 NT mutation | 66(25.8) | 45(24.9) | 21(28.0) | 0.03 |
| PKD2 mutation | 48(18.8) | 29(16.0) | 19(25.3) | 0.48 |
| Mutation not found | 24(9.4) | 12(6.6) | 12(16.0) | 0.58 |
| Unknown | 612(66.7) | 245(63.6) | 267(78.1) | <0.01 |
| PROPKD score | N = 181 | N = 135 | N = 46 | <0.01 |
| 0–3 | 64 (35.4) | 38(28.1) | 26(56.5) | |
| 4–6 | 70(38.7) | 50(37.0) | 20(43.5) | |
| 7–9 | 47(26.0) | 47(34.8) | 0(0) | |
| Missing | 587(76.4) | 292(68.5) | 292(86.3) | <0.01 |
CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; htTKV, height-adjusted total kidney volume; PCR, protein-to-creatinine ratio; PKD1 NT, PKD1 nontruncating; PKD1 PT, PKD1 protein truncating; RP, rapid progressor; SP, slow progressor.