Table. 2. Mucosal Clinical Manifestations in Patients with Neutrophil Defects.

Here we summarize various defects in neutrophil functionality and their effect on distinct infection susceptibility of the host.

Common manifestations in patients with Congenital Neutropenia:

Bacterial Infections; commonly respiratory

Staphylococcus aureus

Streptococci, enterococci, pneumococci

Pseudomonas aeruginosa

Gram negative bacilli

Oral manifestations (inflammatory): Periodontitis, Oral Ulcers

Diffuse gastrointestinal disease- sometimes associated with enteric infection

Common manifestations in patients with Neutrophil motility defects:

Mucosal bacterial infections; Respiratory, GI, Perirectal area

Infections often become necrotic

Staphylococcus aureus and Gram-negative enteric organisms

Oral manifestations (inflammatory): Periodontitis, Oral Ulcers

Common mucosal manifestations in patients with Neutrophil Function Defects:

Defective O2 production

Respiratory infections, Gastrointestinal disease

Bacterial infections, granulomas; Staphylococcus aureus, Burkholderia cepacia

Nocardia species, gram negative enteric bacilli.

Increased risk for infection with mycobacterial species

Invasive fungal infections with molds and yeast (Aspergillus)

Cathepsin C defect

Oral disease; severe periodontitis