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. 2023 Aug 30;25(35):6539–6543. doi: 10.1021/acs.orglett.3c02358

Scheme 3. Scope of the MHAT Coupling-Cyclization Reaction.

Scheme 3

Reaction conditions are as follows: isocyanide/alkene (1:1), Fe(acac)3 (0.2 equiv), PhSiH3 (1 equiv), iPrOH [0.4 M], and TBHP (1.5 equiv) at 60 °C for 24 h.

Reaction conditions are as follows: Fe(acac)3 (1 equiv), PhSiH3 (3 equiv), TBHP (1 equiv), and MTBE/MeOH (0.2 M) at rt for 15 min, then TFA [2 equiv) and alkene (3 equiv) at 60 °C for 2.5 h open to air.

Reaction conditions are as follows: isocyanide/alkene (1:1), Fe(acac)3 (0.2 equiv), PhSiH3 (1 equiv), and iPrOH (0.04 M] at rt for 24 h.