. 2023 Aug 28;25(35):6479–6484. doi: 10.1021/acs.orglett.3c02064

Table 2. Substrate Scope: Variation of the Lactam N-Protecting Group. Addition of Phenylboronic Acid to Lactams (1a–o) with Different N-Protecting Groups^a.

Conditions: Reactions were performed with phenylboronic acid (0.08 mmol, 4 equiv), lactams 1a–o (0.02 mmol), Pd(TFA)₂ (10 mol %), (S)-t-BuPyOx (12 mol %), AgBF₄ (24 mol %), H₂O (5 equiv) in CH₂Cl₂ (0.16 mL) at 30 °C for 16 h. Yield was determined by ¹H NMR relative to 1,3,5-trimethoxybenzene internal standard. ee was determined by chiral SFC.

Table 2. Substrate Scope: Variation of the Lactam N-Protecting Group. Addition of Phenylboronic Acid to Lactams (1a–o) with Different N-Protecting Groupsa.

Table 2. Substrate Scope: Variation of the Lactam N-Protecting Group. Addition of Phenylboronic Acid to Lactams (1a–o) with Different N-Protecting Groups^a.