. 2023 Aug 28;25(35):6479–6484. doi: 10.1021/acs.orglett.3c02064

Table 3. Investigation of the Nucleophile Scope: Addition of Different Arylboronic Acids (4a–n) to Lactam 1f^a.

Conditions: Reactions were performed with phenylboronic acid 4a–n (0.20 mmol, 2.0 equiv), lactam 1f (0.10 mmol), Pd(TFA)₂ (10 mol %), (S)-t-BuPyOx (12 mol %), AgBF₄ (24 mol %), H₂O (0.50 mmol, 5.0 equiv) in CH₂Cl₂ (0.80 mL) at 30 °C for 16 h. Yields are of isolated products after column chromatography. ee was determined by chiral SFC.

Table 3. Investigation of the Nucleophile Scope: Addition of Different Arylboronic Acids (4a–n) to Lactam 1fa.

Table 3. Investigation of the Nucleophile Scope: Addition of Different Arylboronic Acids (4a–n) to Lactam 1f^a.