Table 3.
Multivariate adjusted association between maternal multimorbidity and preterm birth
|
Preterm birth (24 to < 37 w) Adjusted OR (95% CI) |
Moderate preterm (32 to < 37 w) Adjusted OR (95% CI) |
Very preterm (28 to < 32 w) Adjusted OR (95% CI) |
Extremely preterm (24 to < 28 w) Adjusted OR (95% CI) |
|
|---|---|---|---|---|
| Maternal multimorbidity | 1.64 (1.48–1.82) | 1.69 (1.52–1.89) | 1.22 (0.9–1.66) | 0.86 (0.51–1.44) |
| No MM | Ref | Ref | Ref | Ref |
| Adjusted for maternal age, socioeconomic status, ethnicity, number of previous pregnancies, BMI and smoking history. SIMD: Scottish Index of Multiple Deprivation. BMI: body mass index | ||||
| Age at conception, years | ||||
| 15–19 | 1.13 (0.94–1.36) | 1.13 (0.92–1.38) | 1 (0.56–1.78) | 1.79 (0.87–3.7) |
| 20–24 | 1 (0.87–1.14) | 0.97 (0.85–1.12) | 1.22 (0.84–1.79) | 1.37 (0.79–2.38) |
| 25–29 | Ref | Ref | Ref | Ref |
| 30–34 | 1.11 (0.99–1.25) | 1.06 (0.94–1.2) | 1.48 (1.05–2.09) | 1.09 (0.64–1.86) |
| 35–39 | 1.24 (1.08–1.44) | 1.18 (1.01–1.37) | 1.49 (0.97–2.27) | 1.18 (0.61–2.26) |
| 40–44 | 1.72 (1.35–2.21) | 1.7 (1.32–2.2) | 1.14 (0.48–2.71) | 0.73 (0.17–3.21) |
| 45–49 | 1.07 (0.33–3.46) | 1.03 (0.32–3.31) | ISS | ISS |
| SIMD | ||||
| Most deprived 1 | 1.31 (1.1–1.55) | 1.18 (0.99–1.41) | 3.34 (1.73–6.46) | 1.11 (0.53–2.34) |
| 2 | 1.27 (1.07–1.51) | 1.16 (0.97–1.39) | 3.28 (1.69–6.35) | 1.25 (0.59–2.63) |
| 3 | 1.14 (0.95–1.36) | 1.06 (0.88–1.28) | 2.34 (1.18–4.67) | 1.11 (0.51–2.41) |
| 4 | 1.11 (0.93–1.32) | 1.03 (0.86–1.23) | 2.3 (1.16–4.56) | 0.97 (0.44–2.14) |
| Least deprived 5 | Ref | Ref | Ref | Ref |
| Missing | 1.04 (0.85–1.26) | 1 (0.81–1.22) | 2.19 (1.06–4.53) | 0.61 (0.23–1.62) |
| Previous pregnancies | ||||
| 0 | Ref | Ref | Ref | Ref |
| 1 | 0.76 (0.68–0.85) | 0.8 (0.71–0.9) | 0.57 (0.4–0.81) | 0.67 (0.41–1.12) |
| 2 | 0.8 (0.7–0.91) | 0.81 (0.7–0.94) | 0.68 (0.46–1.02) | 0.75 (0.41–1.36) |
| 3 | 0.92 (0.79–1.08) | 0.9 (0.76–1.07) | 1.13 (0.74–1.73) | 0.92 (0.45–1.86) |
| 4 | 1.03 (0.84–1.25) | 1.01 (0.82–1.25) | 1.11 (0.65–1.89) | 1.05 (0.44–2.49) |
| 5 + | 1.27 (1.06–1.53) | 1.13 (0.93–1.38) | 1.41 (0.87–2.29) | 1.84 (0.89–3.79) |
| Unknown | 1.84 (0.23–14.62) | 1.59 (0.36–6.99) | ISS | ISS |
| Ethnicity | ||||
| White | 1.26 (0.61–2.62) | 1.54 (0.67–3.52) | 0.64 (0.16–2.62) | 0.44 (0.06–3.26) |
| Mixed ethnic groups | 1.24 (0.3–5.04) | 1.75 (0.41–7.47) | ISS | ISS |
| Black | Ref | Ref | Ref | Ref |
| Asian | 1.63 (0.75–3.55) | 2 (0.83–4.84) | 0.28 (0.04–1.99) | 1.26 (0.14–11.01) |
| Others | 1.47 (0.66–3.24) | 1.63 (0.66–4) | 0.85 (0.17–4.23) | 0.49 (0.04–5.58) |
| Missing | 1.14 (0.55–2.38) | 1.45 (0.63–3.33) | 0.47 (0.11–1.96) | 0.36 (0.05–2.76) |
| BMI, kg/m2 | ||||
| Underweight (< 18.5) | 1.36 (1.03–1.81) | 1.31 (0.97–1.76) | 1.2 (0.51–2.85) | 1.52 (0.45–5.09) |
| Normal weight (18.5–24.9) | Ref | Ref | Ref | Ref |
| Overweight (25–29.9) | 0.98 (0.86–1.12) | 0.93 (0.81–1.06) | 1.26 (0.88–1.81) | 2.09 (1.23–3.57) |
| Obese(> 30) | 1.11 (0.98–1.26) | 1.05 (0.92–1.2) | 1.34 (0.94–1.93) | 1.67 (0.93–2.98) |
| Missing | 1.31 (1.15–1.49) | 1.28 (1.11–1.47) | 1.23 (0.84–1.82) | 1.52 (0.82–2.81) |
| Smoking history | ||||
| Never smoked | Ref | Ref | Ref | Ref |
| Current smoker | 1.44 (1.28–1.61) | 1.4 (1.24–1.58) | 1.67 (1.22–2.29) | 2.14 (1.33–3.43) |
| Former smoker | 0.85 (0.73–0.99) | 0.89 (0.75–1.04) | 0.93 (0.6–1.45) | 0.79 (0.38–1.67) |
| Not known | 1.4 (1.18–1.65) | 1.31 (1.1–1.56) | 1.52 (0.95–2.45) | 1.94 (0.97–3.89) |
ISS Insufficient Sample Size