Table 2.
Assessment of the characteristic parameters of each biomarker
| Variables | Cutoff point | AUC (95% CI) | SEN (%, 95% CI) | SPE (%, 95% CI) | PPV (%, 95% CI) | NPV (%, 95% CI) | DeLong testd (p-value) |
|---|---|---|---|---|---|---|---|
| NLRa | 5.84 | 0.648 (0.594–0.701) | 65.8 (56.9–74.6) | 60.3 (57.4–63.2) | 14.5 (11.4–17.5) | 94.5 (92.8–96.2) | Reference |
| PLRb | 204.41 | 0.568 (0.507–0.629) | 44.1 (34.9–53.4) | 71.1 (68.4–73.8) | 13.5 (10.0–17.0) | 92.6 (90.8–94.4) | 0.003 |
| SIIc | 1243.07 | 0.614 (0.558–0.671) | 55.9 (46.6–65.1) | 64.2 (61.3–67.0) | 13.7 (10.5–16.9) | 93.4 (91.7–95.2) | 0.042 |
| NEU | 5.85 | 0.605 (0.551–0.660) | 79.3 (71.7–86.8) | 42.7 (39.8–45.7) | 12.4 (10.0–14.8) | 95.3 (93.4–97.2) | 0.049 |
| LYM | 1.12 | 0.604 (0.548–0.661) | 59.5 (50.3–68.6) | 58.2 (55.2–61.1) | 12.7 (9.80–15.5) | 93.4 (91.5–95.2) | 0.037 |
| PLT | 187.50 | 0.537 (0.482–0.592) | 56.8 (47.5–66.0) | 55.1 (52.1–58.0) | 11.4 (8.80–14.1) | 92.6 (90.6–94.6) | 0.006 |
NEU, Neutrophils; LYM, Lymphocyte; PLT, Platelet; CI, confidence interval; AUC, the area under the curve; SEN, Sensitivity; SPE, Specificity; PPV, positive predictive value; NPV, negative predictive value
aNLR = Neutrophil count/Lymphocyte count
bPLR = Platelet count/Lymphocyte count
cSII = (Neutrophil count × Platelet count)/Lymphocyte count
dA comparison of AUC was performed using the DeLong test