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. 2023 Aug 6;19(13):4157–4165. doi: 10.7150/ijbs.86492

Figure 1.

Figure 1

PGE2 synthesis via the Arachidonic Acid pathway. Biosynthesis of prostaglandins. AA is liberated from membrane phospholipids by the action of Phospholipase A2, that is then converted into PGH2 by the action of the Cyclooxygenases, a rate-limiting step for prostaglandin biosynthesis. Prostaglandin H2 (PGH2) is the unstable precursor of Prostaglandin F2 (PGF2), Prostaglandin D2 (PGD2), Prostaglandin I2 (PGI2), Thromboxane A2 (TxA2) and Prostaglandin E2 (PGE2). PGE2 receptors and their related downstream signaling are also shown.