Figure 1.

Sirt3 overexpression attenuates cerebral I/R injury. WT and Sirt3^Tg mice were subjected to transient MCAO. A, B. TTC staining was used to observe the infarction size in the brain after MCAO. C. H&E staining was used to detect histological alterations in the brain after MCAO. D, E. Nissl staining was used to observe the number of Nissl bodies in brain tissues after MCAO. F-I. RNA was isolated from brain tissues, and the levels of IL-6, CRP, TNFα and MCP1 were analyzed. J, K. ELISAs were used to detect GSH and SOD activity levels in brain tissues after MCAO. *p<0.05 vs. sham+WT group, #p<0.05 vs. MCAO+WT group.