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. 2023 Aug 15;19(13):4259–4277. doi: 10.7150/ijbs.85986

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PAI-1 expression in clinical samples and the proposed signalling pathway. (A) PAI-1 expression in tumor samples derived from 107 melanoma patients was determined by IHC staining of a tissue microarray. Samples were sorted into several groups from low to high according to the staining intensity. (B) Percentages of patients with different expression levels of PAI-1 according to sample type. (C) IHC staining of PAI-1 in TNBC tumors. (D) TNBC case percentage from stages I to III based on the expression levels. (E) Case percentages of PAI-1 levels between the non-TNBC and TNBC groups. (F) The schematics illustrate the proposed signalling pathway through which coculture of tumor cells with platelets promotes cell survival, migration, invasion and colony formation capacities in vitro and tumorigenesis and metastasis in mice.