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. 2023 Sep 11;17(1):2253104. doi: 10.1080/19336950.2023.2253104

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© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — a) Network of ion channels and transporters in human T cells. K_V1.3 and K_Ca3.1 are expressed in both the plasma membrane and inner mitochondrial membrane. Although Ca_V3.2, Ca_V3.3, Ca_V2.1 transcripts are present in T cells, they lack many 5’ exons and consequently no functional Ca_V channels are expressed in T cells [10]. This figure is modified and updated from a figure published in [9]. b) The number of K_V1.3 and K_Ca3.1 channels per T cell in quiescent, acutely activated (1–3 rounds of antigenic stimulation) and chronically activated (>4–5 rounds of antigenic stimulation) cells.