Skip to main content
. 2023 Sep 11;17(1):2253104. doi: 10.1080/19336950.2023.2253104

Figure 4.

Figure 4.

Transition from the open-conducting to the non-conducting C-type inactivated state of Shaker-IR, KVChim and KV1.3. a) amino acid sequence alignment of fly Shaker, rat KVChim and human KV1.3. Residues highlighted in gray are involved in the formation of hydrogen bonds that stabilize the open-conducting conformation. b) Shaker-IR (PDB 7SIP) selectivity filter is in an open-conducting conformation (left), while Shaker-W434F (PDB 7SJ1) selectivity filter is in a dilated C-type inactivated conformation (right). c) KVChim (PDB 2R9R) is in the open-conducting conformation (left) and the rapidly inactivating triple mutant (W362F+S367T+V377T) (PDB 7SIT) is in a dilated C-type inactivated conformation (right). d) KV1.3 with two dilated conformations designated D1 (PDB 7SSX) (left) and D2 (PDB 7SSY) (right). The D2 conformation is identical to the C-type inactivated conformation in the KV1.3-KVβ2 structure (cyan).