Fig. 1. Strategy for Cetuximab (CTX) modification (mCTX). CTX was reacted with 12 equivalents of Cy7.5-NHS-ester and 6 equivalents of DBCO-STF-ester in buffer NaHCO3 at pH 8.4, for 16 hours at 4 °C. The isolated reaction product is named mCTX.
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