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The time course of pT-ION induced orofacial allodynia. (A) The schematic diagram of orofacial branch of the trigeminal nerve and pT-ION surgery. (B) and (C) showed the primary and secondary mechanical hyperalgesia induced by pT-ION in the ipsilateral facial V2 and V3 area, respectively. (D) showed the secondary cold allodynia in the ipsilateral facial V3 area. N = 8 mice/group. ***P < 0.001 vs. naive group, two-way ANOVA and Tukey’s test.
