Table 3. MR analyses of gut microbiota-derived metabolites on GDM by different methods.
| Exposure | F statistics | Inverse variance weighted | Maximum likelihood | Weighted median | MR.RAPS | MR Egger | |||||||||
| OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | OR (95%CI) | P | ||||||
| Serine | 34.57 | 2.545 (1.603,3.573) | 0.001 | 2.403 (1.651,3.013) | 0.001 | 2.663 (0.956,7.419) | 0.062 | 2.584 (1.769,3.262) | 0.003 | 1.391 (0.203,9.546) | 0.741 | ||||
| Pyruvate | 17.55 | 0.519 (0.290,0.928) | 0.027 | 0.528 (0.294,0.947) | 0.032 | 0.391 (0.181,0.845) | 0.022 | 0.486 (0.270,0.886)) | 0.021 | 0.179 (0.033,0.977) | 0.075 | ||||
| Pipecolate | 27.65 | 0.531 (0.301,0.937) | 0.029 | 0.537 (0.297,0.974) | 0.043 | 0.840 (0.380,1.855) | 0.671 | 0.605 (0.358,1.023) | 0.063 | 0.552 (0.099,3.96) | 0.522 | ||||
| Indoleacetate | 43.73 | 1.766 (1.054,2.958) | 0.031 | 1.617 (1.000,2.614) | 0.052 | 1.754 (0.936,3.288) | 0.083 | 1.607 (0.658,3.923) | 0.062 | 1.741 (0.904,3.351) | 0.157 | ||||
| Glycodeoxycholate | 15.70 | 0.780 (0.620,0.981) | 0.034 | 0.775 (0.610,0.985) | 0.056 | 0.764 (0.563,1.037) | 0.081 | 0.835 (0.664,1.051) | 0.124 | 0.676 (0.230,1.982) | 0.512 | ||||
| Adrenate | 32.64 | 1.859 (1.024,3.376) | 0.042 | 1.875 (1.022,3.440) | 0.042 | 1.570 (0.732,3.371) | 0.251 | 1.868 (1.005,3.474) | 0.054 | 1.921 (0.423,8.630) | 0.425 | ||||
| Carnitine | 65.99 | 0.479 (0.235,0.975) | 0.042 | 0.480 (0.241,0.956) | 0.045 | 0.515 (0.160,1.662) | 0.272 | 0.522 (0.267,1.021) | 0.067 | 1.026 (0.109,9.657) | 0.981 | ||||
| Phenylacetate | 24.02 | 1.624 (1.015,2.600) | 0.043 | 1.804 (1.142,2.849) | 0.016 | 1.570 (0.732,3.371) | 0.251 | 1.868 (1.005,3.474) | 0.054 | 1.921 (0.423,8.630) | 0.425 | ||||
OR, odds ratio; CI, confidence interval; P, P value; MR, mendelian randomization; MR.RAPS, mendelian randomization robust adjusted profile score; GDM, gestational diabetes mellitus.