TABLE 2.
Summary of Secondary Endpoints in ICU Patients in the Two Groups
| Variables | Ciprofol (n = 88) | Propofol (n = 45) | Median of Difference, % (95% CI) | p |
|---|---|---|---|---|
| Mean time to sedation (min) | 57.5 ± 6.4 | 57.7 ± 6.7 | 0.00 (0.00–0.00) | NA |
| Mean sedation compliance rate (%) | 95.9 ± 10.6 | 96.2 ± 11.2 | 0.00 (0.00–0.00) | NA |
| Extubation time | ||||
| From intubation or admitted to ICU (hr) | 17.5 ± 9.8 | 16.4 ± 5.2 | 0.724 | |
| From the drug withdrawal (hr) | 1.1 ± 1.0 | 1.2 ± 1.1 | 0.718 | |
| Recovery time (min) | 4.8 ± 9.8 | 1.6 ± 2.8 | 0.003 | |
| Usage of study drugs | ||||
| Duration of loading dose (min) | 4.0 ± 0.4 | 4.0 ± 0.1 | 0.266 | |
| Numbers of top-up dose (times) | 0.0 ± 0.2 | 0.1 ± 0.6 | 0556 | |
| Number of patients with ≥ 1 top-up dose, n (%) | 2 (2.3) | 1 (2.2) | 1.000 | |
| Duration of maintenance administration (hr) | 9.8 ± 4.7 | 9.7 ± 4.7 | 0.968 | |
| Number of dose adjustments during maintenance (times) | 0.6 ± 1.2 | 0.6 ± 1.1 | 0.722 | |
| Number of patients with ≥ 1 dose adjustment, n (%) | 29 (33.0) | 17 (37.8) | 0.700 | |
| Overall administration duration of study drugs (hr) | 9.8 ± 4.7 | 9.8 ± 4.7 | 0.964 | |
| Remifentanil dose/min per body weight (μg/kg/min) | 0.04 ± 0.03 | 0.04 ± 0.03 | 0.00 (–0.44 to 0.54) | NA |
| Nursing scores (range, 0–12) | 5.0 ± 1.5 | 5.2 ± 1.2 | 0.090 |
NA = not applicable.
Data are presented as the mean ± sd or numbers with percentages.