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. Author manuscript; available in PMC: 2023 Sep 12.
Published in final edited form as: Brain Behav Immun. 2022 Sep 26;107:16–31. doi: 10.1016/j.bbi.2022.09.014

Fig. 4.

Fig. 4.

ELS impairs phagocytic activity ex vivo. Microglia isolated from the hippocampus of P17 pups were incubated with pHrodo labeled synaptosomes to assess phagocytic activity ex vivo. (A) No synaptosome control used to gate non-phagocytic microglia. Representative scatter plots showing the percentage of fluorescently labeled microglia from CTL (B), LB (C) and UPS (D). (E) Exposure to LB and UPS reduced ex vivo phagocytic activity, an effect that was less pronounced in UPS females. N = 17–22 mice per rearing and sex group. Error bars represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.