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. 2023 Jan 19;41(9):1320–1331. doi: 10.1038/s41587-022-01628-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, Drug conversion potential in the microbiomes of 365 Japanese patients with CRC and 251 controls on the Average Japanese Diet. The violin plots show the distribution of drug metabolite flux in mmol per person per d. b, Drug conversion potential (mmol per person per d) plotted against the total relative abundance of the reaction producing the shown drug metabolite in the 616 microbiomes. See Supplementary Table 5a for a description of each drug-metabolizing enzyme.