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. 2023 Jan 12;41(9):1296–1306. doi: 10.1038/s41587-022-01626-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — a, Phenotype of the 14 AML cell lines used in the study showing the expression of CD64 and CD123 at the cell surface by flow cytometry. Antibody binding capacity (ABC) values for CD123 are indicated. b, Maximum cytotoxic activities of the anti-CD123 antibody (CD123-IgG1+; black), NKp46-Fc null-CD123 NKCE (red), and IgG1 isotype control (IC-IgG1+; white) against AML cell lines. AML cell lines were used as targets and purified NK cells from 4 healthy donors were used as effectors. Data are presented as mean values ± s.d. c, Delta (Δ) maximum lysis, defined as percent maximum lysis of the compound minus percent background lysis of the isotype control molecule (IC-IgG1⁺) at the corresponding concentration, were monitored from the dose response of each compound, and were plotted separately for all couples of CD64⁻positive and CD64-negative AML cell lines/NK donor. (ns P > 0.05; **** P ≤ 0.0001; two-sided Wilcoxon matched-pairs signed rank test).