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. 2023 Aug 7;30(9):1380–1392. doi: 10.1038/s41594-023-01047-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig 8 — a, Interaction of pentacycline on the SSU head at 1.89 Å. b-d, Superimposition of pentacycline from (a) with (b) tetracycline on the SSU head determined at 1.8 Å (from Fig. 2), (c) eravacycline on the SSU head determined at 2.2 Å (from Fig. 4), and (d) omadacycline on the SSU head determined at 2.1 Å (from Fig. 4), e-f, Zoom of the coordination of the Mg2 for (e) omadacycline and (f) pentacycline. g, Interaction of evernimicin (Evn) on the LSU at 1.9 Å. h, Superimposition of evernimicin (Evn) from (g) with avilamycin (Avi) (from Fig. 3). i, Superimposition of Evn (blue) from (g) with previous structures of Evn in complex with the ribosome (PDB ID 5KCS and 5JVH)^43,44. j, Interaction of iboxamycin (green) on the 70S ribosome at 2.5 Å (PDB ID 7RQ8)⁴⁶. k-l, superimposition of iboxamycin (green) from (j) with (k) clindamycin (light blue) and (l) lincomycin (dark blue) determined here at 2.0 Å and 1.6 Å, respectively.