Figure 1.

Sequences of 22–25 d fetuses edited at Exon 2 (a) or Exon 5 (b). Top sequence for each sample shows the reference sequence with target region(s) outlined in red in the initial part of the translated region. The lower sequence for each sample indicates the actual sequence for that fetus with sequencing traces included for some fetuses in each group. (a) As indicated by the two outlined target regions, fertilized zygotes were electroporated with a combination of two guide RNAs targeting Exon 2. (b) An additional fetus with some mosaicism is not included.