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. 2023 Sep 12;14:5615. doi: 10.1038/s41467-023-41265-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overview of the multi-contact Nano-C assay, which combines multiplexed capture of 3 C molecules containing pre-selected viewpoints, their linear amplification and their single-molecule direct-RNA sequencing. b Stringent three-step filtering of Nano-C reads to identify bona-fide chromatin interactions. c Captured pair-wise (1-way) and multi-way (≥2-way) contacts. d Genomic distribution of multi-way Nano-C contacts. Further analysis in this study is limited to the 25% of multi-contacts that have at least two contacts in the TADs directly surrounding the viewpoints.