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. 2023 Sep 12;14:5615. doi: 10.1038/s41467-023-41265-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a 1D representation of multi-contacts. The Nano-C viewpoint is indicated with a black box and the identified contacts with red boxes. The gray line connects all contacts, thereby indicating the genomic interval that is spanned. b Nano-C multi-contacts in WT mESCs surrounding a central viewpoint within a large TAD with little CTCF binding. Violin plot indicates distances of up- and downstream interactions (white lines: median distances). Dashed purple lines indicate TAD boundaries. The viewpoint and Hi-C data are indicated on top. CTCF ChIP-seq data is indicated below. c Nano-C multi-contacts in 2 TADs surrounding a viewpoint that is close to a TAD boundary in WT (top, red) and Rad21-AID (bottom, blue) mESCs. Violin plots indicate distances of up- and downstream interactions of the viewpoint. The thick purple line indicates the boundary of interest and the thinner line a nearby boundary. Top: WT Hi-C data. In-between: WT CTCF and Rad21 ChIP-seq data, and Hi-C insulation score (red line: cut-off). d Shortest and longest distances within Nano-C multi-contacts in WT and Rad21-AID mESCs. Violin plots show the distance distributions for the combined 13 viewpoints (dashed white lines: median distance). Lines between violin plots connect pairs of shortest and longest distances within the same multi-contact. Number of data points and the Spearman correlation score are indicated in the top-left corner.