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. 2023 Sep 12;14:5603. doi: 10.1038/s41467-023-41376-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The structure of LASV particle. B LASV L (green and yellow) and S (purple and multi-color for the GPC) segments. C SDS PAGE gel image of in vitro transcribed prefusion and wild-type LASC GPC vaccine constructs. This was run once. D Animal study outline: schedule for two doses of vaccine, challenge, and end of study. Each group included 5 animals, for a total of 25 animals in the study. The animals were 4–6 weeks old and had a starting weight of 350–400 g. The control group received two doses of sterile phosphate-buffered saline. Graphics were generated by N. Lloyd with Biorender.com and Microsoft PowerPoint.