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. 2023 Sep 13;13:294. doi: 10.1038/s41398-023-02582-4

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A This figure depicts the selected deregulated biological processes targeted by co-expressed miRs of black, yellow and red modules. Selected deregulated biological processes are enriched for inflammation, VEGF signaling, synaptic assembly and axon guidance. B The overlap among target genes of co-expressed miR modules. C Hypergeometric overlap of the co-expressed miR module target genes with genes related with depression based on human genome-wide association studies and transcriptional-based study. Fisher’s exact test was performed, and the data are presented with a Benjamini Hochberg (BH) corrected p-value. A color map illustrates the significance and overlap strength. The PsyGeNEt database was utilized to identify genes associated with depression and TRD.