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. 2023 Sep 12;14:5624. doi: 10.1038/s41467-023-41342-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–c IFN-γ levels collected before (6-month round; green) or after (12-month round; yellow) of the third dose administration, represented in log10(mIU/ml), in infection-naive individuals (n = 115 and n = 650 biologically independent samples before and after the third dose administration) (a), individuals previously infected with a variant before Omicron (n = 23 and n = 122 biologically independent samples before and after the third dose administration) (b), and in individuals infected with Omicron (n = 23 and n = 98 biologically independent samples before and after the third dose administration) (c). Circles represent observed data. Data reported as median and interquartile range (box), whiskers represent 1.5 times the interquartile range. Dashed horizontal line indicates assay positivity threshold. P-values were calculated using Mann-Whitney U test (two-sided). Correlation between IFN-γ levels with IgG (d) and IgA levels (e) at 6-month round. Correlation between IFN-γ levels with IgG (f) and IgA levels (g) at 12-month round. Blue, red, yellow colors represent infection-naive individuals, individuals infected before Omicron, and individuals infected with Omicron, respectively. Black color represents overall Spearman Rank test results. Circles represent observed data. Shadowed areas represent the 95% confidence interval. P-values were calculated using Spearman Rank test (two-sided). p < 0.05 was considered statistically significant. Source data are provided as a Source Data file.