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. 2023 Sep 12;14:5624. doi: 10.1038/s41467-023-41342-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Distribution of IgG levels (a) and IgA levels (b), both represented as log10(AU/ml) (n = 22 and n = 163 biologically independent samples in the reinfected with Omicron and infected with Omicron groups, respectively); neutralizing antibody levels (c), represented as log10(IU/ml) (n = 22 and n = 161 biologically independent samples in the reinfected with Omicron and infected with Omicron groups, respectively); and IFN-γ levels (d), represented in log10(mIU/ml) (n = 13 and n = 98 biologically independent samples in the reinfected with Omicron and infected with Omicron groups, respectively); generated after the third dose (day 15 after the third dose) in individuals infected before Omicron who were reinfected with Omicron (Reinfected with Omicron) and individuals infected with Omicron for the first time (Infected with Omicron) at the 12-month round. Green and yellow colors represent reinfected with Omicron and infected with Omicron, respectively. Circles represent observed data. Data reported as the median and interquartile range (box), whiskers represent 1.5 times the interquartile range. Dashed horizontal line indicates the threshold for assay positivity. P-values were calculated using Mann-Whitney U test (two-sided), where p < 0.05 was considered significant. Source data are provided as a Source Data file.