TABLE 4.

Alignment of L1 protein amino acid sequences corresponding to the different strains used to produce recombinant VLPs with the sequence of the HPV-16 L1 prototype (27)^a

HPV-16 strain	L1 amino acid at positionb:
	76	78	83	97	176	181	194	202	266	282	319	346	353	422	474
Prototype	His	Pro	Phe	Arg	Thr	As	Val	His	Thr	Ser	His	Ser	Ala	Thr	Leu
114K	-	-	-	-	-	-	-	Asp	-	-	-	-	-	-	-
Phi1	-	-	-	-	-	-	-	Asp	-	-	-	-	-	-	-
114B	-	-	-	-	-	-	Ile	Asp	Ala	-	-	-	-	-	-
Tha7	-	Arg	-	-	Asn	-	-	Asp	-	-	-	-	Pro	-	-
Alg1	-	-	-	Trp	-	-	-	Asp	-	-	Arg	-	-	-	Phe
Z-1194	Tyr	-	-	-	Asn	Thr	-	Asp	Ala	Pro	-	-	Pro	-	Phe
Sen32	Tyr	-	-	-	Asn	-	-	Asp	Ala	-	Arg	Val	-	Ala	Phe
Fra25	Tyr	-	Ser	-	Asn	-	-	Asp	Ala	-	Arg	Val	-	Ala	Phe
Fra63	Tyr	-	-	-	Asn	-	-	Asp	Ala	-	Arg	Val	-	Ala	Phe

^aThe sequences of strains 114K and 114B (17) and Z-1194 (7) have been published previously. 

^bA hyphen indicates that the amino acid is identical to that of the prototype strain.