Table 1.
Recommended core clinical data.
| MINIMUM | MINIMUM PLUS | CORE | EXTENDED | |
|---|---|---|---|---|
| Demographics (e.g., NINDS CDE General Core)16 | ✓ | ✓ | ✓ | ✓ |
| Recruitment category (Case/Control) | ✓ | ✓ | ✓ | ✓ |
| Family History | ✓ | ✓ | ✓ | ✓ |
| Diagnostic checklist (MDS clinical diagnosis criteria17 or UK Parkinson’s Disease Society Brain Bank Diagnostic Criteria)18 | ✓ | ✓ | ✓ | |
| Primary diagnosis and PD certainty (PPMI Primary Clinical Diagnosis)10 | ✓ | ✓ | ✓ | |
| PD history (e.g., NINDS CDE for Parkinson’s Disease)16 | ✓ | ✓ | ✓ | |
| Global PD severity (CISI-PD)19 | ✓ | ✓ | ✓ | |
| Behavioral and Environmental History (PD-RFQ-U)16 | ✓ | ✓ | ||
| Medical History | ✓ | ✓ | ||
| Current Medication Status | ✓ | ✓ | ||
| nM-EDL (MDS-UPDRS Part I [or UPDRS])20,21 | ✓ | ✓ | ||
| M-EDL (MDS-UPDRS Part II [or UPDRS])20,21 | ✓ | ✓ | ||
| Motor Assessment (MDS-UPDRS Part III [or UPDRS])20,21 | ✓ | ✓ | ||
| Complications (MDS-UPDRS Part IV [or UPDRS])20,21 | ✓ | ✓ | ||
| Cognitive Assessment (MMSE, MoCA)22,23 | ✓ | ✓ | ||
| Motor (Hoehn and Yahr stage)24 | ✓ | ✓ | ||
| Autonomic function assessment (SCOPA-AUT)25 | ✓ | ✓ | ||
| pRBD (RBDSQ)26 | ✓ | ✓ | ||
| Day time sleepiness (ESS)27 | ✓ | |||
| Depression (GDS-15)28 | ✓ | |||
| Orthostatic hypotension (Standing/sitting/supine HR and BP) | ✓ | |||
| Olfactory function (UPSIT or Sniffin-stick or BSIT)29–31 | ✓ | |||
| General ADL (Schwab & England ADL)32 | ✓ | |||
| PD EQL (PDQ-8)33 | ✓ | |||
| Pain (Kings PD Pain Scale)34 | ✓ |