Figure 1.

Removal of circulating CPPs using the alendronate column in nephrectomized miniature pigs. (a) A schematic representation of extracorporeal circulation using the alendronate column or the control column. Blood sampling was performed at the inlet (In) and the outlet (Out) of the column 30 min after starting the extracorporeal circulation. Plasma CPP levels were determined by the gel-filtration method³. (b) Difference in the plasma CPP levels between the inlet and the outlet. The alendronate column, but not the control column, adsorbed CPPs. N = 4 for each group, *P = 0.028 by paired t-test. (c) A schematic representation of the hemodialysis circuit using the alendronate column. (d) Difference in the plasma CPP levels between the inlet (In) and the outlet (Out) of the column at the indicated time points after starting hemodialysis. The data from two pigs were expressed as percent of the CPP levels before starting hemodialysis (median with range).