Table 3.
Changes in physical and metabolic variables after intervention
| Day | Placebo (n = 12) |
Faecal filtrate (n = 12) |
p-value | |
|---|---|---|---|---|
| BMI (kg/m2) | 0 | 35.8 (4.0) | 35.3 (5.6) | 0.75 |
| 28 | 36.1 (3.9) | 35.3 (5.8) | – | |
| WHR | 0 | 0.97 (0.09) | 0.99 (0.07) | 0.58 |
| 28 | 0.97 (0.09) | 0.99 (0.08) | – | |
| Systolic BP (mmHg) | 0 | 134 (15) | 130 (17) | 0.39 |
| 28 | 134 (16) | 126 (17) | – | |
| Diastolic BP (mmHg) | 0 | 88 (11) | 83 (14) | 0.37 |
| 28 | 86 (9) | 84 (14) | – | |
| Pulse (beats/min) | 0 | 66 (9) | 70 (13) | 0.33 |
| 28 | 65 (10) | 70 (11) | – | |
| Glucose (mmol/L) | 0 | 5.5 (0.4) | 5.8 (0.5) | 0.19 |
| 28 | 5.7 (0.5) | 5.9 (0.5) | – | |
| Insulin (nmol/L) | 0 | 71 (34) | 72 (26) | 0.76 |
| 28 | 87 (30) | 93 (34) | – | |
| p-value | – | 0.036 | 0.007 | – |
| HOMA-IR | 0 | 2.41 (1.21) | 2.57 (0.97) | 0.55 |
| 28 | 3.05 (1.06) | 3.41 (1.28) | – | |
| p-value | 0.047 | 0.008 | – | |
| HbA1c (mmol/mol) | 0 | 36.8 (2.6) | 35.4 (4.7) | 0.53 |
| 28 | 35.5 (2.5) | 35.0 (4.5) | – | |
| Cholesterol (mmol/L) | 0 | 4.87 (0.79) | 5.38 (1.32) | 0.28 |
| 28 | 4.92 (0.78) | 5.33 (1.15) | – | |
| HDL (mmol/L) | 0 | 1.05 (0.20) | 1.14 (0.18) | 0.41 |
| 28 | 1.15 (0.30) | 1.21 (0.17) | – | |
| p-value | – | 0.005 | 0.064 | – |
| LDL (mmol/L) | 0 | 3.06 (0.77) | 3.43 (1.08) | 0.32 |
| 28 | 3.03 (0.88) | 3.42 (0.99) | – | |
| Triglycerides (mmol/L) | 0 | 1.68 (0.61) | 1.80 (0.61) | 0.96 |
| 28 | 1.66 (0.88) | 1.56 (0.64) | – | |
| CRP (mg/L) | 0 | 3.0 (2.6) | 5.1 (4.6) | 0.17 |
| 28 | 2.9 (2.9) | 4.6 (3.4) | – |
Unless otherwise specified, data are reported as mean (SD). Mixed model analyses were used to assess differences between groups and timepoints, whereafter post hoc analyses were performed with Bonferroni correction. All tests were two-sided. The p-values in the right column shows the overall effect of treatment on the variable and only when significant, the adjusted p-values from the post hoc tests are shown. The p-values underneath variables indicate statistically significant differences between days 0 and 28 within a treatment group. Source data are provided in the Source Data file.
BMI Body Mass Index, WHR waist-hip ratio, BP blood pressure, HOMA-IR Homeostatic Model Assessment for Insulin Resistance, HDL high-density lipoprotein, LDL low-density lipoprotein, CRP C-reactive protein.