Table 3.
Univariate and multivariate analysis.
| Parameters | Univariate | Multivariate (forward conditional) | ||||||
|---|---|---|---|---|---|---|---|---|
| Sig. | Exp (B) | 95% CI for Exp (B) | Sig. | Exp (B) | 95% CI for Exp (B) | |||
| Male gender | 0.852 | 0.951 | 0.564 | 1.606 | ||||
| Age | 0.392 | 0.990 | 0.967 | 1.013 | ||||
| Bismuth I–II | 0.881 | Ref. | ||||||
| Bismuth III–IV | 0.624 | 0.823 | 0.378 | 1.791 | ||||
| Distal CCA | 0.923 | 1.051 | 0.385 | 2.867 | ||||
| Localization unknown | 0.634 | 0.682 | 0.141 | 3.291 | ||||
| M0 vs. M1 | 0.523 | 0.968 | 0.874 | 1.071 | ||||
| Hepatic metastatic disease | 0.955 | 1.027 | 0.408 | 2.587 | ||||
| ECOG 0 vs. >0 | 0.183 | 1.438 | 0.843 | 2.452 | ||||
| Total bilirubin (<1.5 vs. >1.5) | 0.821 | 1.063 | 0.627 | 1.801 | ||||
| CA19-9 (<250 vs. >250) | 0.268 | 0.737 | 0.430 | 1.264 | ||||
| MELD-Score (<6.5 vs. >6.5) | 0.766 | 1.084 | 0.638 | 1.841 | ||||
| eRFA | 0.021 | 0.515 | 0.293 | 0.905 | 0.037 | 0.416 | 0.183 | 0.947 |
| ePDT | 0.994 | 1.002 | 0.593 | 1.695 | ||||
| 1 line vs. >1 line SC | 0.030 | 0.523 | 0.291 | 0.939 | ||||
| No surgery | 0.108 | Ref. | ||||||
| Surgery with tumor resection | 0.046 | 0.534 | 0.289 | 0.989 | ||||
| Surgery without tumor resection | 0.043 | 0.348 | 0.125 | 0.966 | ||||
| Palliative surgery | 0.660 | 0.822 | 0.343 | 1.971 | ||||
| R0 vs. R1 | 0.204 | 0.899 | 0.764 | 1.059 | ||||
| Metal stent implantation | 0.006 | 0.416 | 0.223 | 0.777 | 0.037 | 0.406 | 0.174 | 0.948 |
| ORR | 0.800 | 0.907 | 0.426 | 1.932 | ||||
| DCR | 0.027 | 0.526 | 0.297 | 0.930 | ||||
| First-line dose reduction over time | 0.509 | 0.823 | 0.461 | 1.468 | ||||
| Tumor grading 1/2 vs. 3/4 | 0.020 | 2.260 | 1.138 | 4.489 | ||||
CA19-9, carbohydrate antigen 19-9; CCA, cholangiocarcinoma; DCR, disease control rate; ECOG, Eastern Cooperative Oncology Group performance status; ePDT, endobiliary photodynamic therapy; eRFA, endobiliary radio-frequency ablation; MELD, model for end-stage liver disease; ORR, objective response rate; SC, systemic chemotherapy.Statistically significant P-Values are displayed in bold values.