Table 4.
Adverse events.
| Parameters | SC + ePDT (N = 22) |
SC + eRFA (N = 28) |
SC + ePDT + eRFA (N = 13) |
P-value | |||
|---|---|---|---|---|---|---|---|
| N | % | N | % | N | % | ||
| Leucopenia | 4 | 19.0% | 5 | 17.9% | 3 | 23.1% | 0.917 |
| Thrombopenia | 11 | 52.4% | 8 | 28.6% | 2 | 15.4% | 0.106 |
| Anemia | 12 | 57.1% | 11 | 39.3% | 3 | 23.1% | 0.231 |
| Neutropenia | 7 | 33.3% | 5 | 17.9% | 2 | 15.4% | 0.434 |
| Other hematotoxic side effects | 0 | 0.0% | 3 | 10.7% | 0 | 0.0% | 0.147 |
| ALT elevation | 7 | 33.3% | 3 | 10.7% | 3 | 23.1% | 0.178 |
| AST elevation | 1 | 4.8% | 0 | 0.0% | 0 | 0.0% | 0.389 |
| Ascites | 3 | 14.3% | 3 | 10.7% | 1 | 7.7% | 0.889 |
| Hepatic dysfunction | 0 | 0.0% | 2 | 7.1% | 0 | 0.0% | 0.285 |
| Anorexia | 2 | 9.5% | 2 | 7.1% | 1 | 7.7% | 0.968 |
| Fatigue | 1 | 4.8% | 2 | 7.1% | 0 | 0.0% | 0.626 |
| Nausea | 1 | 4.8% | 6 | 21.4% | 2 | 15.4% | 0.236 |
| Vomit | 2 | 9.5% | 5 | 17.9% | 2 | 15.4% | 0.664 |
| Creatinine elevation | 0 | 0.0% | 2 | 7.1% | 0 | 0.0% | 0.296 |
| Chronic kidney failure | 2 | 9.5% | 1 | 3.6% | 0 | 0.0% | 0.456 |
| Skin rash | 1 | 4.8% | 1 | 3.6% | 0 | 0.0% | 0.766 |
| Diarrhea | 0 | 0.0% | 2 | 7.1% | 1 | 7.7% | 0.415 |
| Edema | 0 | 0.0% | 0 | 0.0% | 1 | 7.7% | 0.120 |
| Mucositis | 1 | 4.8% | 0 | 0.0% | 1 | 7.7% | 0.357 |
| Allergic reaction | 1 | 4.8% | 1 | 3.6% | 0 | 0.0% | 0.766 |
| Infection without neutropenia | 11 | 52.4% | 12 | 42.9% | 3 | 23.1% | 0.366 |
| Infection with neutropenia | 0 | 0.0% | 2 | 7.1% | 0 | 0.0% | 0.285 |
| Deep vein thrombosis | 1 | 4.8% | 1 | 3.6% | 0 | 0.0% | 0.766 |
| Thromboembolic event | 6 | 28.6% | 3 | 10.7% | 0 | 0.0% | 0.072 |
| Hyperbilirubinemia | 2 | 9.5% | 2 | 7.1% | 3 | 23.1% | 0.256 |
| Jaundice | 1 | 4.8% | 2 | 7.1% | 0 | 0.0% | 0.623 |
| Abdominal pain | 6 | 28.6% | 10 | 35.7% | 0 | 0.0% | 0.052 |
| Cholangitis | 5 | 23.8% | 17 | 60.7% | 5 | 38.5% | 0.025 |
| Biliary sepsis | 5 | 23.8% | 2 | 7.1% | 3 | 23.1% | 0.215 |
| Infection (other than cholangitis) | 6 | 28.6% | 3 | 10.7% | 1 | 7.7% | 0.205 |
| Weight loss | 0 | 0.0% | 1 | 3.6% | 1 | 7.7% | 0.425 |
| Pains | 6 | 28.6% | 7 | 25.0% | 2 | 15.4% | 0.772 |
| Pleural effusion | 1 | 4.8% | 1 | 3.6% | 0 | 0.0% | 0.766 |
| Hypertension | 1 | 4.8% | 0 | 0.0% | 1 | 7.7% | 0.369 |
| Fever | 6 | 28.6% | 4 | 14.3% | 3 | 23.1% | 0.537 |
| Ileus | 1 | 4.8% | 0 | 0.0% | 2 | 15.4% | 0.084 |
| Phototoxic reaction | 4 | 18.2% | 3 | 23.1% | 1.000 | ||
Statistically significant P-Values are displayed in bold values.