Table 2.

Final best-fitting generalized additive mixed-effects model for the NCANDA sample.

	Parametric coefficients							Smooth terms
	Estimate	Std Error	95% CI		t-value	p-value		edf	F-stat	p-value
Accumbens ∼ s(age, by = sex) + sex
Intercept	-0.3599	0.2290			-1.57	0.1160	s(age): female	1.00	60.58	< 0.0001
Sex (male)	0.5309	0.0553	0.4224	0.6393	9.59	< 0.0001	s(age): male	2.80	5.29	0.0069
Amygdala ∼ s(age,) + sex
Intercept	-0.5303	0.0549			-9.66	< 0.0001	s(age)	4.24	23.80	< 0.0001
Sex (male)	1.0382	0.0566	0.9273	1.1491	18.35	< 0.0001
Caudate ∼ s(age, by = sex) + sex + alcohol + alcohol:sex
Intercept	-0.3086	0.0967			-3.19	0.0014	s(age): female	5.13	310.90	< 0.0001
Sex (male)	0.6329	0.0628	0.5098	0.7559	10.08	< 0.0001	s(age): male	2.90	356.60	< 0.0001
Alcohol	-0.0208	0.0043	-0.0292	-0.0124	-4.84	< 0.0001
Alcohol: Sex (male)	0.0163	0.0056	0.0053	0.0273	2.89	0.0038
Hippocampus ∼ s(age, by = sex) + sex + alcohol
Intercept	-0.4360	0.0642			-6.79	< 0.0001	s(age): female	3.39	32.84	< 0.0001
Sex (male)	0.9278	0.0561	0.8179	1.0377	16.55	< 0.0001	s(age): male	4.54	8.93	< 0.0001
Alcohol	-0.0152	0.0036	-0.0223	-0.0082	-4.23	< 0.0001
Pallidum ∼ s(age, by = sex) + sex
Intercept	-0.2896	0.1647			-1.76	0.0787	s(age): female	3.70	5.00	0.0006
Sex (male)	0.5157	0.0627	0.3929	0.6385	8.23	< 0.0001	s(age): male	1.00	57.53	< 0.0001
Putamen ∼ s(age) + sex + alcohol + alcohol:sex
Intercept	-0.4749	0.0698			-6.81	< 0.0001	s(age)	4.96	275.50	< 0.0001
Sex (male)	0.8929	0.0596	0.7761	1.0097	14.98	< 0.0001
Alcohol	-0.0165	0.0085	-0.0331	0.0002	-1.94	0.0526
Alcohol: Sex (male)	0.0265	0.0100	0.0070	0.0460	2.66	0.0078
Thalamus ∼ s(age) + sex + alcohol + alcohol:sex
Intercept	-0.4341	0.0450			-9.64	< 0.0001	s(age)	4.41	46.36	< 0.0001
Sex (male)	0.8615	0.0603	0.7433	0.9797	14.29	< 0.0001
Alcohol	-0.0317	0.0074	-0.0462	-0.0172	-4.28	< 0.0001
Alcohol: Sex (male)	0.0222	0.0087	0.0052	0.0393	2.55	0.0107