TABLE 5.

Lipid intervention targets and management recommendations.

Recommendation	Recommended classification	Evidence level
LDL-C as a primary target for ASCVD risk intervention (Cholesterol Treatment Trialists Collaboration, 2015; Silverman et al., 2016; Navarese et al., 2018)	Ⅰ	A
Non-HDL-C as a target for ASCVD risk intervention in patients with diabetes, metabolic syndrome, high TG, and VLDL-C (Boekholdt et al., 2012; Thanassoulis et al., 2014)	Ⅰ	B
ApoB as a secondary target for ASCVD risk intervention in patients with diabetes, metabolic syndrome, high TG, and VLDL-C (Boekholdt et al., 2012; Thanassoulis et al., 2014)	Ⅱa	C
High TG as an indicator for management of patients at high risk of ASCVD after LDL-C reaching the target (Keech et al., 2005; Jun et al., 2010; Bhatt et al., 2019)	Ⅱa	B
High Lp(a) as an indicator for the management of patients at high risk of ASCVD (Emerging Risk Factors Collaboration, 2009; Willeit et al., 2014)	Ⅱa	C
HDL-C is not recommended as a target for intervention	Ⅲ	A

LDL-C: low-density lipoprotein cholesterol; ASCVD: atherosclerotic cardiovascular disease; HDL-C: high-density lipoprotein cholesterol; ApoB: apolipoprotein B; TG: triglycerides; Lp(a): lipoprotein(a).