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. 2023 Aug 24;13:1209111. doi: 10.3389/fonc.2023.1209111

Table 2.

Comparison of clinical characteristics between the high Ki-67 expression group and low Ki-67 expression group in training and validation groups.

Variables Training Group P Validation Group P
High Ki-67 Low Ki-67 High Ki-67 Low Ki-67
Age(year) 64.61 ± 12.19 64.58 ± 10.49 0.992 62.16 ± 6.86 70.35 ± 10.89 0.012*
Sex 0.989 0.199
Male 37 29 12 14
Female 9 7 7 3
HBsAg 0.544 0.090
Positive 29 25 16 10
Negative 17 11 3 7
AFP (mg/mL) 2739.34 ± 12637.85 1077.99 ± 5666.61 0.471 1861.95 ± 6613.78 351.69 ± 961.05 0.371
Alb (g/L) 38.5 ± 4.39 38.91 ± 4.5 0.685 38.88 ± 4.83 38.8 ± 3.03 0.955
ALT(IU/L) 37.83 ± 26.06 47.1 ± 41.67 0.227 39.25 ± 56.07 26.62 ± 17.36 0.393
AST(IU/L) 40.86 ± 24.24 49.87 ± 44.26 0.25 46.75 ± 77.93 38.31 ± 21.91 0.678
TBIL
(µmol/L)
18.18 ± 22.51 17.64 ± 9.48 0.893 17.41 ± 12.43 13.16 ± 5.9 0.22
DBIL
(µmol/L)
6.58 ± 13.31 6.35 ± 4.79 0.924 5.22 ± 4.0 5.62 ± 5.63 0.81
PT (s) 12.97 ± 1.14 13.33 ± 1.33 0.196 13.44 ± 1.9 12.84 ± 1.29 0.289
INR
Tumor Size
(cm)
1.04 ± 0.1 1.06 ± 0.11 0.306 1.07 ± 0.2 1.05 ± 0.09 0.68
Cirrhosis 0.696 0.158
Absent 21 18 9 12
Present 25 18 10 5
Multifocality 0.362 0.797
Absent 36 31 15 14
Present 10 5 4 4

AFP, alpha fetoprotein; ALB, albumin level; ALT, alanine aminotransferase; AST, aspartate aminotransferase; TBIL, total bilirubin; DBIL, directed bilirubin; PT, prothrombin time; INR, international normalized ratio.