Fig. 5.

Patients with deviating cellular proportions have altered clinical chemistry. A, Principal component analysis biplots of the estimated cell proportions for the 56 human liver samples. Green indicates livers that deviate from the average liver cell type proportions. Arrows indicate the loading vectors. The numbers in parentheses represent the percentage of variability explained by each principal component. B, Immune response markers in patient blood samples (n = 56). Note the agreement between the enhanced immune cell proportion identified by deconvolution and the high levels of inflammatory markers in patient #23. C, Fibrosis markers identified in the patient proteomes (n = 56). Note the agreement between the increased stellate cell proportions and the altered composition of extracellular matrix proteins in patients’ number #39 and #44. Coloured symbols indicate outlier patients of interest, while grey symbols denote the other patients.