Table 3. Linear Associations Between Sedentary Behavior Patterns and Incident Dementiaa.
| Mean, h | Minimally adjusted modelb | Fully adjusted modelc | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Incidence of dementia at mean (95% CI)d | Change in incidence (95% CI)e | HR (95% CI) | P value | Incidence of dementia at mean (95% CI)d | Change in incidence (95% CI)e | HR (95% CI) | P value | ||
| Sedentary bouts per day | 25.78 | 1.20 (1.03 to 1.41) | −0.001 (−0.009 to 0.006) | 1.00 (0.99 to 1.01) | .74 | 1.22 (1.03 to 1.45) | −0.001 (−0.009 to 0.008) | 1.00 (0.99 to 1.01) | .89 |
| Sedentary bout length | |||||||||
| Mean daily | 0.48 | 1.64 (1.36 to 1.97) | 0.99 (0.27 to 2.04) | 1.80 (1.22 to 2.65) | .003 | 1.51 (1.25 to 1.83) | 0.65 (0.04 to 1.57) | 1.53 (1.03 to 2.27) | .04 |
| Maximum daily | 1.95 | 1.83 (1.45 to 2.33) | 0.28 (0.10 to 0.47) | 1.22 (1.08 to 1.38) | .001 | 1.64 (1.29 to 2.09) | 0.19 (0.02 to 0.38) | 1.15 (1.02 to 1.31) | .02 |
Abbreviation: HR, hazard ratio.
a
There were 414 cases of dementia over 334 937 person-years.
b
Adjusted for age and sex.
c
Adjusted for age, sex, education, Townsend Deprivation Index, presence of APOE ε4 allele, ethnicity, chronic conditions (heart or vascular disease, diabetes, cancer), self-reported health, smoking status, alcohol consumption, diet, body mass index, depression, and time spent engaged in moderate to vigorous physical activity.
d
Calculated as dementia cases per 1000 person-years at the mean value for each variable.
e
Calculated as dementia cases per 1000 person-years for each additional hour of mean and maximum sedentary bout length, and for each additional sedentary bout per day.