Table E.1.

Human equivalent doses (HED) in mg/kg bw per day calculated from doses applied and organ contents determined in Cravedi et al. (2017) in comparison to the human organ contents determined in Barp et al. (2014)

Tissue concentrations (mg/kg): F344 rats (Cravedi et al., 2017)
Dose group ca. (mg/kg bw per day)	230	25	2.6	230	25	2.6	230	25	2.6
	Liver			Spleen			Adipose tissue
S‐C25	14,639	4,784	–	499	287	–	347	88.1	–
L‐C25	3,805	1,393	–	419	192	–	36	12.8	–
Broad mixture	5,511	1,604	220	383	202	32	274	95	13
Tissue concentrations (mg/kg): Humans (Barp et al.,  2014 )
	Liver (mg/kg)			Spleen (mg/kg)			Adipose tissue (mg/kg)
Max content	901			1,400			493
Min content	14			6			17
Median content	71			28			87
Human equivalent doses (mg/kg bw per day)
	Liver, median (min–max)			Spleen, median (min–max)			Adipose tissue, median (min–max)
Max content in human organ	3.5 (1.2–14)			46 (28–210)			82 (25–787)
Median content in human organ	0.28 (0.093–1.1)			0.91 (0.57–4.2)			14 (4.4–139)