Table E.7.
Organ burden and overall body burden (in mg) in F344 rats after subacute to subchronic exposure towards MOSH with different compositions. Overall retention of MOSH in the animals as percentage of overall body burden to the ingested MOSH during the study
| Study | Test item | Dose in mg/kg feed | Dose in mg/kg bw per day | Liver burden in mg | Spleen burden in mg | MLN burden in mg | Fat tissue burden in mg | Carcass burden in mg | Fat tissue + carcass burden in mg | Overall body burden in mg | Overall retention in % ingested MOSH |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Cravedi et al. (2017), narrow mixtures | L‐C25 | 394 | 25 | 9.5 | 0.1 | n.m. | 0.1 | 1.7 | 1.8 | 11 | 2.5 |
| L‐C25 | 985 | 62 | 17.9 | 0.2 | n.m. | 0.1 | 3.6 | 3.7 | 22 | 1.9 | |
| L‐C25 | 3,731 | 236 | 26.0 | 0.3 | n.m. | 0.2 | 2.7 | 3.0 | 29 | 0.7 | |
| S‐C25 | 368 | 23 | 35.6 | 0.2 | n.m. | 0.9 | 8.5 | 9.4 | 45 | 10.4 | |
| S‐C25 | 939 | 61 | 72.5 | 0.5 | n.m. | 1.2 | 14.3 | 15.5 | 89 | 7.7 | |
| S‐C25 | 3,630 | 226 | 122.6 | 0.6 | n.m. | 2.8 | 20.7 | 23.5 | 147 | 3.4 | |
| L‐C25W | 350 | 22 | 39.0 | 0.1 | n.m. | 0.7 | 6.8 | 7.5 | 47 | 11.3 | |
| L‐C25W | 836 | 53 | 61.8 | 0.2 | n.m. | 0.7 | 8.8 | 9.6 | 72 | 7.3 | |
| L‐C25W | 3,372 | 218 | 70.0 | 0.3 | n.m. | 1.3 | 13.3 | 14.6 | 85 | 2.1 | |
| Cravedi et al. (2017), broad mixture | Broad, day 30 | 37 | 2.6 | 0.7 | 0.0 | n.m. | 0.1 | – | 0.5 | 1.2 | 10.9 |
| Broad, day 30 | 361 | 25 | 5.6 | 0.0 | n.m. | 0.5 | – | 1.8 | 7.5 | 6.9 | |
| Broad, day 30 | 3,641 | 260 | 15 | 0.1 | n.m. | 2.4 | – | 7.0 | 22 | 2.0 | |
| Broad, day 60 | 37 | 2.6 | 1.1 | 0.0 | n.m. | 0.1 | – | 0.5 | 1.6 | 7.5 | |
| Broad, day 60 | 361 | 25 | 7.2 | 0.1 | n.m. | 0.8 | – | 2.5 | 9.8 | 4.6 | |
| Broad, day 60 | 3,641 | 260 | 22 | 0.1 | n.m. | 3.3 | – | 11 | 33 | 1.5 | |
| Broad, day 90 | 37 | 2.6 | 1.6 | 0.0 | n.m. | 0.2 | – | 0.7 | 2.3 | 7.1 | |
| Broad, day 90 | 361 | 25 | 9.6 | 0.1 | n.m. | 1.0 | – | 3.2 | 13 | 4.1 | |
| Broad, day 90 | 3,641 | 260 | 38 | 0.2 | n.m. | 4.2 | – | 10 | 48 | 1.5 | |
| Broad, day 120 | 37 | 2.6 | 1.4 | 0.0 | n.m. | 0.3 | – | 1.2 | 2.7 | 6.2 | |
| Broad, day 120 | 361 | 25 | 10 | 0.1 | n.m. | 2.3 | – | 4.0 | 14 | 3.5 | |
| Broad, day 120 | 3,641 | 260 | 41 | 0.3 | n.m. | 6.0 | – | 22 | 63 | 1.5 | |
|
Smith et al. (1996) |
Control 1 | 0 | 0 | 2.3 | n.d. | 0.1 | 2.7 | n.m. | – | 5.0 | – |
| Control 2 | 0 | 0 | 1.0 | n.d. | 0.0 | n.m. | n.m. | – | 1.0 | – | |
| Control 3 | 0 | 0 | 1.8 | n.d. | 0.0 | n.m. | n.m. | – | 1.8 | – | |
| N10A | 20,000 | 1,951 | 12.6 | n.d. | 0.4 | 9.5 | n.m. | – | 22 | 0.1 | |
| N15H | 20,000 | 1,951 | 34.6 | n.d. | 0.4 | 9.3 | n.m. | – | 44 | 0.2 | |
| P15H | 20,000 | 1,951 | 23.0 | n.d. | 0.5 | 9.9 | n.m. | – | 33 | 0.2 | |
| N70A | 20,000 | 1,951 | 28.2 | n.d. | 0.4 | 3.8 | n.m. | – | 32 | 0.2 | |
| N70H | 20,000 | 1,951 | 23.2 | n.d. | 0.2 | 4.7 | n.m. | – | 28 | 0.2 | |
| P70H | 20,000 | 1,951 | 6.6 | n.d. | 0.2 | n.m. | n.m. | – | 6.8 | 0.04 | |
| P100H | 20,000 | 1,951 | 3.9 | n.d. | 0.1 | 3.4 | n.m. | – | 7.4 | 0.04 | |
| LMPW 1 | 20,000 | 1,951 | 62.5 | n.d. | 0.4 | 11.5 | n.m. | – | 74 | 0.4 | |
| LMPW 2 | 20,000 | 1,951 | 141.5 | n.d. | 0.6 | n.m. | n.m. | – | 142 | 0.8 | |
| MP | 20,000 | 1,951 | 73.1 | n.d. | 0.3 | n.m. | n.m. | – | 73 | 0.4 | |
| IMPW | 20,000 | 1,951 | 76.8 | n.d. | 0.3 | n.m. | n.m. | – | 77 | 0.4 | |
| HSW | 20,000 | 1,951 | 3.5 | n.d. | 0.0 | 1.6 | n.m. | – | 5.2 | 0.03 | |
| HMPW | 20,000 | 1,951 | 1.1 | n.d. | 0.0 | 9.0 | n.m. | – | 10 | 0.06 |
n.m.: not measured; n.d.: not detected; −: not applicable.