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. 2023 Feb 8;46(5):100580. doi: 10.1016/j.bj.2023.01.004

Fig. 2.

Fig. 2

NLRP3 inhibition with MCC950 attenuated IBD-like symptoms in DSS-induced mice (n = 11) (A) Diagram for the experimental protocol (B) Representative diarrhea (C) Disease activity index during DSS consumption (D) Representative colon length and (E) statistical results (F) H&E staining and (G) histopathological scores of distal colons (Red arrow indicates crypt destruction, yellow arrow indicates epithelial barrier disruption, and blue arrow indicates goblet cell reduction. Scale bar = 200 μm above, Scale bar = 50 μm below). #p < 0.05 and ##p < 0.01 compared with Normal-vehicle group; ∗p < 0.05 and ∗∗p < 0.01 compared with the DSS-vehicle group.