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MCC950 inhibited DSS-induced NLRP3 pathway and decreased pro-inflammatory cytokines in distal colon (n = 5) (A) NLRP3 (B) ASC (C) Caspase-1 (D) IL-1β (E) IL-6 (F) TNF-α. #p < 0.05 and ##p < 0.01 compared with Normal-vehicle group; ∗p < 0.05 and ∗∗p < 0.01 compared with the DSS-vehicle group.
