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MCC950 inhibited DSS-induced NLRP3/ASC/IL-1β signaling pathway in distal colon (n = 4). Representative immunostaining images of (A) NLRP3 (B) ASC, and (C) IL-1β. ##p < 0.01 compared with Normal-vehicle group; ∗p < 0.05, ∗∗p < 0.01 and ∼p = 0.083 compared with the DSS-vehicle group.
