Reaction optimizationa.
| ||
|---|---|---|
| Entry | Variation from standard conditions | Yieldb (%) |
| 1 | None | 74 |
| 2 | Ts-ABZ as limiting reagent | 69 |
| 3 | 2a as limiting reagent | 44 |
| 4 | C = 0.05 M | 74 |
| 5 | C = 0.2 M | 60 |
| 6 | Room temperature | 50 |
| 7 | No BF3·Et2O | 49 |
| 8 | No light or photocatalyst | <5 |
Reactions were carried out on 0.1 mmol scale. Light irradiation was carried out using a single Kessil lamp.
NMR yield determined using CH2Br2 as internal standard.