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Circadian entrainers of colon function. A range of influences may entrain or modulate peripheral clocks underlying circadian rhythms of colonic functions. This schematic diagram summarizes those influences, citing supporting studies. Several influences, such as the vagal and pelvic efferent and afferent pathways remain to be studied in detail for their potential role in driving colonic function rhythmicity. Gut-CNS schematic based on Young (2012).
