Fig. 5.

Effects of SAE1 on the proliferation and invasion in vitro. A-B CCK8 assays to test cell growth viability of SAE1 knockdown or overexpression RBE and CCLP1 cells. C-D Apoptosis rate detected by flow cytometry in SAE1 knockdown or overexpression cells. E-F Cell cycle detected by flow cytometry in Circ-RAPGEF5 knockdown or overexpression cells. G-H The migration ability of Circ-RAPGEF5 knockdown or overexpression RBE and CCLP1 were assessed by transwell assay. I-J The invasion ability was assessed by transwell assay. All data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001