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. 2023 Sep 13;42:239. doi: 10.1186/s13046-023-02813-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Circ-RAPGEF5 exerts its carcinogenic effects on ICC cells by promoting SAE1. A CCK-8 cell viability assay for RBE and CCLP1 cells transfected with Si-NC or Si-Circ-RAPGEF5 and vector or SAE1. B EdU labelling assays for RBE and CCLP1 cells transfected with Si-NC or Si-Circ-RAPGEF5 and vector or SAE1. C Colony formation assays for RBE and CCLP1 cells transfected with Si-NC or Si-Circ-RAPGEF5 and vector or SAE1. D Matrigel-coated transwell assays for RBE and CCLP1 cells transfected with Si-NC or Si-Circ-RAPGEF5 and vector or SAE1. All data are presented as the means ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001