Table 2.
Inflammatory cell count among HC, ACO, asthma, COPD-ES, COPD-CS, and NLFS
| HC | ACO | Asthma | COPD-ES | COPD-CS | NLFS | |
|---|---|---|---|---|---|---|
| Macrophage | ||||||
| Epithelium | 0 9 (0.5–9.3) | 4.3 (0.5–19.4) | 1.2 (0–11.6) | 0.9 (0–3.2) | 1.5 (0–11.7) | 3.2 (0–11.9) |
| RBM | 0.5 (0–2.7) | 4.3 (0–13.4) | 1.8 (0–9.1) | 0.2 (0.-2.8) | 0 (0–2.3) | 0.1 (0–4.9) |
| LP | 192.1 (33.0–429.7 | 265.6 (6.0–556.2) | 186.8 (0–510.7) | 170.5 (31.6–436.2) | 124.6 (18.9–307.1) | 206.9 (13.4–429.4) |
| Neutrophils | ||||||
| Epithelium | 0.5 (0–10.3) | 0 (0–1.1) | 0 | 0.4 (0–2.1) | 0 (0–7.6) | 0.5 (0–5.7) |
| RBM | 3.0 (0–13.3) | 0 (0–1.0) | 0 | 0.9 (0–7.0) | 0.6 (0–10.3) | 2.5 (0–9.6) |
| LP | 128.8 (0–637.7) | 0 (0–57.5) | 0 (0–7.9) | 73.24 (0–260.5) | 26.25 (0–403.7) | 95.84 (19.8–184.7) |
| Eosinophils | ||||||
| Epithelium | 1.4 (0–3.5) | 0.3 (0–5.9) | 0.6 (0–12.9) | 0.3 (0–1.9) | 0.5 (0–13.3) | 0.8 (0–4.3) |
| RBM | 1.3 (0–6.1) | 0.9 (0–21.9) | 2.2 (0–10.5) | 0.6 (0–3.7) | 1.0 (0–16.1) | 1.2 (0–8.5) |
| LP | 185.8 (24.6–394.6) | 87.01 (18.4–200.5) | 144.7 (22.6–903.8) | 52.73 (23.8–131.4) | 70.40 (0–301.6) | 110.7 (12.4–405.7) |
| Mast cells | ||||||
| Epithelium | 4.3 (0–20.3) | 1.7 (0–4.2) | 0 (0–11.9) | 4.7 (0–23.2) | 5.7 (0–14.0) | 6.5 (0–20.2) |
| RBM | 3.7 (0.5–5.4) | 2.2 (0–5.5) | 1.4 (0–8.3) | 4.6 (0.8–15.9) | 6.4 (0–11.3) | 8.5 (0.8–14.9) |
| LP | 305.9 (99.6–549.6) | 108.5 (0–451-8) | 150.2 (5.6–649.6) | 267.5 (48.6–551.6) | 256.9 (0–374.5) | 265.9(140.4–481.0) |
| CD8 + T-cells | ||||||
| Epithelium | 3.7 (0–13.6) | 10.0 (0–19.1) | 3.3 (0–12.7) | 5.0 (0–38.2) | 5.4 (0–23.0) | 6.7 (0–21.8) |
| RBM | 0 (0- 4.0) | 1.7 (0–5.8) | 2.5 (0–7.4) | 0.3 (0–1.9 | 0.6 (0–2.1) | 0 (0–1.1) |
| LP | 116.6 (24.1–532.2 | 119.5 (32.3–328.8) | 107.4 (13.9–515.6) | 180.0 (38.0–417.0) | 136.2 (14.7–183.0) | 93.62 (4.9–319.3) |
| CD4 + T-cells | ||||||
| Epithelium | 0 (0–1.7) | 0 (0–0.7) | 0 (0–4.0) | 0 (0–3.2) | 0 (0–1.0) | 0 (0–4.2) |
| RBM | 0 (0–1.2) | 0 (0–1.9) | 0 (0–2.8) | 0 | 0 | 0 (0–0.4) |
| LP | 12.5 (0–217.2) | 6.0 (0–133.7) | 0 (0–83.4) | 0.8 (0–118) | 0 (0–98.9) | 6.3 (0–84) |
Data presented as median (minimum – maximum)
ACO asthma COPD overlap, COPD chronic obstructive pulmonary disease, COPD-CS COPD current smokers, COPD-ES. COPD ex-smokers, RBM reticular basement membrane, LP lamina propria, NLFS normal lung function smoker