Table 3. Studies reporting IOS during AC (200 cases or more).

HIC: High-income country

Author, year	Number of Cases	IOS rate	Significantly Associated Predictors/Risk Factors	Reporting region
Current Study	200	3.5%	No significant association was found	LMIC
Lanthier, 2021 [4]	581	5%	Tumor location (frontal lobe), preoperative radiotherapy, preoperative use of antiepileptic drugs, intraoperative use of dexmedetomidine, intraoperative stimulation mapping	HIC
Blanshard, 2000 [11]	241	6.2%	-	HIC
Choi, 2019 [12]	416	24%	Alterations in genes coding for Recepter Tryosine Kinsase History of seizures and preoperative use of antiepileptics were negatively associated	HIC
Boetto, 2015 [13]	374	3.4%	No significant association was found	HIC
Nossek, 2013 [5]	477	12.6 %	History of seizures, tumor location (frontal lobe), young age	HIC
Sacko, 2011 [14]	214	5.7%	-
Jumper, 2011 [15]	611	3%	History of seizures, tumor location (frontal lobe)	HIC
Kim, 2009 [16]	309	9%	History of seizures	HIC
Serletis, 2007 [17]	610	11.8%	-	HIC