Semi-quantitative recording of architectural damage on histopathological analysis of the liver of control and treated^a.

Groups	Control	Acetaminophen	Soft coral	Acetaminophen + soft coral	Acetaminophen + silymarin
Hepatic necrosis	—	+++	—	+	+
Inflammatory infiltration	—	+++	—	—	—
Congestion and dilatation of sinusoids	—	+++	—	—	—
Pyknotic nuclei	—	+++	—	+	+
Proliferation of Kupffer cells	—	+++	—	+	+

^aHistological grading was made according to four severity grades: − (none); + (mild); ++ (moderate) and +++ (severe).